![]() These data suggest that the administration of specific commensal epitopes may help to widen the repertoire of specific T regs that control intestinal inflammation. Using this approach, we found that antigens from Akkermansia muciniphila reprogram nave CD4 T cells to the T reg lineage, expand preexisting microbe specific T regs, and limit wasting disease in the CD4 T cell transfer model of colitis. Here, we used a new approach to study epitopes and identify T cell receptors expressed by CD4 Foxp3 (T reg ) cells specific for commensal-derived antigens. However, clinical interventions targeting commensal bacteriaspecific CD4 T cells are rare, because only a very limited number of commensal-derived epitopes have been identified. CD4 T cells are critical to sustain uninterrupted tolerance to microbial antigens and to prevent intestinal inflammation. ![]()
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